~ Meline's House ~: May 2017

Vitacal Forte ®

Increasing bone density & growth

The health and strength of our bones rely on a balanced diet and a steady stream of nutrients, most importantly, calcium and Vitamin D. But some other nutrients like zinc, Magnesium, Manganese, Copper, Boron and Vitamin K are also vital for bone formation and mineralization.

Indications:

Promotes bone growth and mineralization
Increases bone density
Helps prevent osteoporosis and bone loss.

Ingredients:

Calcium

Calcium is a major constituent of bones and teeth. Some 99% of calcium is found in the skeleton. The mineral component of bone consists mainly of hydroxyapatite [Ca10(PO4)6(OH)2] crystals, which contain large amounts of calcium, phosphorus, and oxygen. Bone mineral density (BMD) increases during the first three decades of life, reaching its peak at about the age of 30. After this age, BMD declines, and the decline increase more rapidly in women after the menopause. However BMD also declines in older men. Circulating calcium concentrations are tightly controlled by the parathyroid hormone (PTH) and vitamin D at the expense of the skeleton when dietary calcium intakes are inadequate. The skeleton is a reserve of calcium drawn upon to maintain normal serum calcium in case of inadequate dietary calcium. Thus, calcium sufficiency is required to maximize the attainment of peak bone mass during growth and to prevent the progressive demineralization of bones later in life, which leads to osteoporosis, bone fragility, and an increased risk of fractures. The spine, hips, ribs, and wrists are common areas of bone fractures. Meta-analyses report that calcium supplementation reduces bone loss by 0.5-1.2% and the risk of fracture of all types by at least 10% in older people.

Data from observational studies and randomized controlled trials support calcium supplementation in reducing the risk of high blood pressure and preeclampsia in pregnant women. The World Health Organization advises that all pregnant women in areas of low calcium intake (i.e., low-income countries with intakes around 300-600 mg/day) be given supplemental calcium starting in the 20thweek of pregnancy.

Current available data suggest that adequate calcium intakes may play a role in body weight regulation and have therapeutic benefits in the management of moderate-to-severe premenstrual symptoms.

Vitamin D3

Vitamin D is a fat-soluble vitamin that regulates calcium and phosphorus homeostasis and bone health along with parathyroid hormone and calcitonin. While it can also be obtained from dietary sources or supplements, vitamin D₃ (cholecalciferol) is synthesized in the human skin from 7-dehydrocholesterol upon exposure to ultraviolet-B (UVB) radiation from sunlight. The body needs vitamin D in its active form (1,25-dihydroxyvitamin D; calcitriol) for effectively absorb dietary calcium. Increased circulating 1,25-dihydroxyvitamin D in turn stimulates increased intestinal absorption of both calcium and phosphorus, limits the urinary excretion of calcium by increasing its reabsorption in the kidneys and also mobilizing calcium from bone when there is insufficient dietary calcium.

Zinc

Zinc has a stimulatory effect on bone formation and mineralization. Hydroxyapatite crystals also contain zinc along with other transition metals. Zinc deficiency decreases bone weight and results in a retardation of bone growth, development, and maintenance of bone health. It decreases bone resorption and stimulates alkaline phosphatase (ALP) activity. Zinc functions as a metal component of alkaline phosphatase. Alkaline phosphatase structure incorporates 4 zinc atoms per molecule, 2 of which are essential for enzyme activity. Zinc may induce the increase in alkaline phosphatase-related DNA synthesis and, as a result, stimulate bone growth. Zinc demonstrates stimulating cell proliferation and differentiation, as well as protein synthesis in osteoblatic cells, while at the same time inhibits osteoclast differentiation. Zinc also stimulates collagen synthesis needed for bone matrix formation. Studies have also shown that zinc levels are positively correlated with Insulin-like growth factor (IGF-1) .The evidence suggests that zinc stimulates the release of IGF-1. In fact, the impaired growth and poor bone health associated with zinc deficiency is believed to be due to low levels of circulating IGF-1 that leads to loss of calcium from bones and increased risk of osteoporosis and bone fractures.

Magnesium

About 60% of total Mg is stored in the bone either on the surface of hydroxyapatite or in the hydration shell around the crystal which comprises about 1% of bone mineral. It influences both bone matrix and bone mineral metabolism. As the magnesium content of bone mineral decreases, apatite crystals of bone become larger and more brittle. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and bone cells and also result in low serum calcium levels indirectly by impacting on the secretion and the activity of parathyroid hormone. Controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity. A study of over 900 elderly men and women found that higher dietary magnesium intakes were associated with increased BMD at the hip in both men and women.

Manganese

This mineral is involved in the formation of the bone framework structure contributing to the organic component of the osseous matrix. It is the preferred cofactor of enzymes called glycosyl transferases; these enzymes are required for the synthesis of proteoglycans that are needed for the formation of healthy cartilage and bone.

Vitamin K

In the past decade it has become evident that vitamin K can improve bone health. The human intervention studies have demonstrated that vitamin K can not only increase bone mineral density in osteoporotic people but also actually reduces fracture rates. Several mechanisms are suggested by which vitamin K can modulate bone metabolism. Vitamin K is the essential cofactor for the carboxylation of glutamate to gamma-carboxyglutamic acid (Gla), and activates the vitamin K–dependent Gla-containing proteins which associated with the coming together of cartilage and bone. Adequate amounts of vitamin K is also needed in order to activate osteocalcin that is responsible for binding calcium ions to the matrix of bone. Studies showed that bone fractures in both women and men are reduced in correlation with higher levels of vitamin K. A deficiency of Vitamin K is associated with increased risk of hip fractures in the elderly and low bone mineral density (BMD) caused by high levels of under-carboxylated osteocalcin.

Beta carotene

Vitamin A is necessary for cells to differentiate normally, normal skeletal growth and bone remodeling process. Osteoblast and osteoclasts have receptors for retinoic acid. In contrast, too much vitamin A can cause bone loss and increases the risk of hip fracture. The animal source supplements (retinols) may cause toxicity but B carotene does not.

Boron

Boron appears to be important in calcium metabolism, and can affect the composition, structure and strength of bone. It may also influence the metabolism of Calcium, magnesium and vitamin D. Some studies suggested that boron is a safe and effective treatment for some forms of arthritis. The initial evidence was that boron supplementation alleviated osteoarthritic pain and discomfort.

Copper

Copper is required for the maintenance of healthy bone tissue. This mineral is also involved in the formation of the bone framework structure contributing to the organic component of the osseous matrix. It functions in lysil oxidase, an enzyme essential for cross linking of collagen fibrils.


Supplement Facts

Amount per tablet		RDA%
Ca (Calcium carbonate)	600	60
Vitamin D3	400 IU	67
Vitamin K1	50 mcg	55
Boron	1 mg	*
Cu (Copper gluconate)	1 mg	110
Zn (Zinc gluconate )	10 mg	125
Mg (Magnesium oxide)	50 mg	15
Mn (Manganese sulphate)	5 mg	278
Betacarotene	1 mg	*

Administration:

Take one tablet daily with meal.

Pregnancy and Lactation:

This product is safe to use by pregnant or lactating women.

Pregnant or lactating women should consult a physician before using this product.

NeuroGain Neurogain PB 孕妇德国深海鱼油DHA 孕妇鱼油 30粒

DHA Supplement for pregnant and lactating women

(DHA 提供孕期和哺乳期妇女)

【主要成分】含有丰富的DHA、鱼肝油和维生素E

250 mg DHA

20mg EPA

18mg AA

30 mgOA

怀孕期间和哺乳期间最好一直服用，可经产检医生推荐，自行到西药药剂行购买；直邮可提供西药药行购买凭证，充足产品质量保证，直接邮寄到您所提供的地址，非国内现货购买前请认准，对胎儿负责是一辈子的事情。

【产品优势】

Neurogain是根据国际世界卫生组织标准（WHO&ISSFAL）

对于生命初期所需的必需脂肪酸配制而成。与普通含浓缩DHA鱼油不同之处是NeuroGain具有高浓缩DHA，低EPA, AA, OA，让孕妈妈安全服用，特别是胎儿在宫内生长的生命初期。NeuroGain是根据国际世界卫生组织标准配置而成，是特别为孕妈妈制造的DHA产品。

此款DHA是德国生产，在马来西亚包装。

产检医生推荐的孕妈妈DHA补充剂。

建议有条件的妈妈在咨询过医生的意见之后从怀孕就可以吃了，每天一粒，宝宝的脑部发育在怀孕期间得到很好的营养，让我们的宝宝从出生开始就领先一步
【规格】30粒/瓶
【使用剂量】每天吃饭的时候吃一粒，或者可根据个人情况遵照医生的嘱咐

什么是DHA？

DHA，即不饱和脂肪酸（二十二碳六烯酸），被形象的称之为“脑黄金”，DHA能提高记忆力和判断力，可促进大脑和视神经系统的发育，增强脑细胞活力，提高智力和视力。

人脑中的DHA大量存在于人体视网膜及大脑皮层，是儿童脑部及视力发育的重要组成部分。婴幼儿对DHA的需要主要来自母体和母乳，所以补充足够的DHA有利于宝宝的脑部发育。

孕期为什么要补充DHA？

孕期补充足够的DHA可以促进胎儿脑细胞和视网膜的发育，以及促进胎儿心理运动技能的发育

DHA能优化胎儿大脑锥体细胞的磷脂的构成成分，尤其是胎儿满5个月以后，如人为地对胎儿的视觉、听觉、触觉进行刺激，会引起胎儿大脑皮层感觉中枢的神经元增长更多的树突，这就需要母体供给胎儿更多的DHA